Author:
Degenhart H. J.,Visser H. K. A.,Boon H.,O'Doherty N. J.
Abstract
ABSTRACT
Enzyme preparations were isolated from post-mortem adrenal tissue of a patient with lipoid adrenal hyperplasia and normal human- and bovine adrenal tissue. Cholesterol-cleaving properties were studied in incubation experiments with the addition of appropriate substrates. Cholesterol-cleaving activity of enzyme preparations of adrenal tissue from the patient was extremely low as compared with normal controls. There was no difference in 20α-hydroxycholesterol-cleaving activity. There is thus evidence for a deficient 20α-cholesterol-hydroxylase activity in the adrenal tissue of this patient with lipoid adrenal hyperplasia.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
96 articles.
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