UNTERSUCHUNGEN ZUR GLUCONEOGENETISCHEN WIRKUNG VON CORTISOL

Abstract

ABSTRACT The cortisol conditioned liver glycogen development was investigated within a time limit through the use of intact starved rats, which were made artificial diabetics with alloxan, and which were adrenalectomized. The liver glycogen and blood glucose concentration showed after one oral insertion of cortisol phased changes, which indicates endocrine counter-reactions. The insulin-like activity in plasma which was investigated through the use of intact rats showed an increase, while the cortisol conditioned induction of the liver – tryptophan-pyrrolase from endocrine regulations was not influenced, the cortisol conditioned liver glycogen development represented itself as a combined reaction of primary and secondary effects. An insular reaction obviously follows a primary gluconeogenetic one. Then an adrenalic counter-regulation results. These factors ascertain the degree and duration of the liver glycogen sedimentation.