PROGESTERONE IN THE UTERUS

Abstract

ABSTRACT The radioactive substances obtained from subcellular uterine fractions and from plasma were separated and identified by analytical TLC's, chemical reactions and crystallization to constant activity 5 min, 20 min and 3 h after the injection of [1,2-3H]progesterone into oestradiol-primed castrated Wistar rats. It was found that the radioactive progesterone remained unchanged in all uterine fractions during these times. In plasma, metabolites were found 5 min, 20 min and 3 h after injection of labelled progesterone. In these studies radio-metabolites of progesterone could not be observed in the uterus of normal rats under the applied conditions, but only in the plasma.