POST HEPARIN PLASMA LIPOPROTEIN LIPASE ACTIVITY IN THYROID DISEASE

Author:

Kirkeby Knut,Bjerkedal Inger

Abstract

ABSTRACT Plasma post heparin lipoprotein lipase activity (LLA) has been studied in patients with hyper- and hypothyroidism and in rabbits made thyrotoxic with thyroxine. The hypothyroid patients had high triglyceride and low LLA values as compared with a control group of healthy subjects. Statistically highly significant negative correlation was found between the triglycerides in fasting patients and the post heparin LLA, indicating a causal relationship, possibly with disturbance of chylomicron degradation due to low LLA in the arterial wall. However, relatively low LLA values were also demonstrated in hyperthyroid patients as well as in rabbits following treatment with thyroxine for 3 weeks. A stimulating effect of the thyroid hormones on the synthesis and degradation of lipoprotein lipase may be a possible explanation for these apparently contradictory findings.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

Cited by 30 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Relation Between Plasma Lipid Levels and Pseudocholinesterase Activity in Hypothyroidism;Hormone and Metabolic Research;1998-03

2. Lipids and Lipoproteins in Thyroid Dysfunction;Recent Developments in Lipid and Lipoprotein Research;1993

3. High muscle lipoprotein lipase activity in thyrotoxic patients;Acta Endocrinologica;1985-06

4. Treatment of hyperthyroidism: Effects on hepatic lipase, lipoprotein lipase, LCAT and plasma lipoproteins;Scandinavian Journal of Clinical and Laboratory Investigation;1984-01

5. The effect of altered thyroid status on lipid metabolism in nubian goats;Comparative Biochemistry and Physiology Part B: Comparative Biochemistry;1984-01

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