Author:
Melville Edith,Kelly R. W.,Mitchell F. L.
Abstract
ABSTRACT
A possible pathway for the synthesis of cortisol in utero and in early infancy, via Δ5 steroidal intermediates has been suggested by the tentative identification of hydroxylated derivatives of 3β-hydroxy-5-pregnen-20-one. The penultimate compound in such a pathway (3β,11β,17α,21-tetrahydroxy-5-pregnen-20-one) has been searched for in blood from umbilical cords and in infant urine. None could be detected at a level of 0.5 μg/100 ml.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
3 articles.
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1. Conversion of 11β, 17α, 21-trihydroxy-4-pregnene-3, 20-dione-4-14C to 3β, 11β, 17α, 21-tetrahydroxy-5-pregnen-20-one-14C by reversal of the 3β-hydroxysteroid dehydrogenase-isomerase reactions;Steroids;1972-12
2. The development of steroidogenesis;The American Journal of Medicine;1972-11
3. Conversion of 17α,21-dihydroxy-4-pregnene-3,20-dione-4-14C to 3β,17α,21-trihydroxy-5-pregnen-20-one-14C by reversal of the 3β-hydroxysteroid dehydrogenase-isomerase reactions;Steroids;1972-07