INFLUENCE OF TESTOSTERONE, PROGESTERONE AND OESTRADIOL ON THE F. S. H.-RELEASE OF HYPOPHYSES GRAFTED UNDER THE KIDNEY CAPSULE

Abstract

ABSTRACT Hypophyses transplanted under the kidney capsule rapidly lose their F. S. H.-content. This decrease is counteracted by the administration of testosterone (17β-hydroxy-androst-4-en-3-one); an increase was even observed in the F. S. H.-content of the grafts. Treatment with progesterone (pregn-4-ene-3,20-dione) resulted in a non-significant increase in the F. S. H.-content of the grafts. Oestradiol was able to counteract to some extent the effect brought about by testosterone. These results point to a direct action on pituitary F.S.H.-release-capacity, at least for testosterone.