Author:
Buckler J. M. H.,Clayton Barbara E.
Abstract
ABSTRACT
The cross reaction of follicle stimulating hormone (FSH) with antisera raised to human chorionic gonadotrophin (HCG) for use in the radioimmunoassay of luteinising hormone (LH) has been found to be influenced by many factors. These include the relative concentration of the hormones, the concentration of antiserum, the length of the assay stages, and the particular preparation of FSH. Antisera do not react identically with HCG and LH. This effect varies from antiserum to antiserum and so does the ability to detect the immunological differences which become apparent between different preparations of FSH and between hormones of urinary and pituitary origin. These findings are of considerable relevance to the assessment of the validity of a radioimmunoassay system.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
3 articles.
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