SIGNIFIKANTE VERÄNDERUNG DES ALKALISCHEN LEUKOZYTENPHOSPHATASE-INDEX WÄHREND DES MENSTRUELLEN ZYKLUS

Abstract

ABSTRACT For the determination of alcaline phosphatase of leucocytes (ALP) blood smears from 5 menstruating women, 2 pregnant women, 1 postmenopausal woman, and 3 men were examined daily during some cycles or for a period of several months. In contrast to the males and the postmenopausal woman, the women with a regular menstrual cycle show a significant increase in ALP starting approximately at the 15th day after the onset of the menstruation bleeding and lasting for 3–5 days. The maximum level corresponded to the time of ovulation. Furthermore there was a good correlation between the ALP-values with the known amounts of oestrogens excreted during a normal menstrual cycle. Therefore the cytochemical determination of ALP provides a rapid additional method for testing the ovarial function when carried out daily. When the single ALP determination is done, like in routine clinical analysis, consideration should be given to the day of the cycle when the sample was taken.