INFLUENCE OF AN ANTIANDROGEN (CYPROTERONE) ON THE GONADOTROPHIC FUNCTION OF THE PITUITARY GLAND, ON THE GONADS AND ON METABOLISM IN NORMAL MEN

Abstract

ABSTRACT Treatment with Cyproterone 200 mg/d induced no increase of total gonadotrophins in normal subjects. Plasma testosterone was elevated during the period of treatment. An alteration in the ratio LH/FSH has been suggested. Urinary 17-KS showed no uniform pattern, but 17-KGS were always significantly elevated during Cyproterone treatment. Seminal fluid examinations showed no effect of Cyproterone (100 and 200 mg/d, total dose 4.2–38.6 g within 9 months) on spermatogenesis in 6 adults with normal gonadal function. No increase of spermatogenesis has been observed under treatment with Cyproterone (100 mg and 200 mg/d, total dose 3.5–35.4 g within 8 months) in 7 patients with oligospermia. Over a period of 21 days no influence of Cyproterone (200 mg/d) has been observed on the function of adrenal cortex, concerning cortisol- and aldosterone production, on the carbohydrate and lipid metabolism and on liver function in 5 subjects.