THE RELATIVE EFFECTS OF CORTISONE AND TRIAMCINOLONE (9α-FLUORO-16α-HYDROXYPREDNISOLONE) ON THE URINARY EXCRETION OF TRYPSIN INHIBITOR IN MAN

Abstract

ABSTRACT The dose-response relationships between oral triamcinolone and cortisone acetate and the urinary trypsin inhibitor excretion have been compared in two normal women. It was found that 6 and 2 mg of triamcinolone, respectively, had the same effect as about 100 mg of cortisone acetate, giving ratios of activity between triamcinolone and cortisone of about 15/1 and 45/1. These ratios of effect are much larger than those which have been found in man for other functions affected by glucocorticoids including the therapeutic effects. The relative effect in man of triamcinolone can therefore apparently vary from function to function as has also been found in experimental animals. Increasing doses of exogenous glucocorticoid produce increasing excretions of trypsin inhibitor, but only within limited dose ranges. The maximal effect of cortisone acetate was obtained with a daily dose of about 100 mg, whereas the maximal effect in the two subjects was obtained with different doses of triamcinolone, but in both cases with amounts equivalent to about 100 mg of cortisone acetate.