MALE EXTERNAL GENITALIA OF A GIRL CAUSED BY A VIRILIZING ADRENAL TUMOUR IN THE MOTHER

Abstract

ABSTRACT A 7-year-old normal looking »boy« presented bilateral cyptorchidism. At surgery female internal genitalia (uterus, Fallopian tubes, ovaries) were found. The caryotype was 46 XX. Congenital adrenal hyperplasia could be excluded and no androgens or gestagens were given to the mother during pregnancy. The mother in spite of regular menstrual cycles showed some signs of virilization. Further examination revealed the presence of an adrenal cortical adenoma in the mother. To our knowledge, this is the first case of complete masculinization of a girl caused by an adrenal tumour in the mother.