Author:
Sarkar G. C.,Mukherjee Geeta
Abstract
ABSTRACT
The in vitro effects of oestradiol and progesterone on the incorporation of H3 32PO4 into full term placental nucleic acids were studied. Oestradiol in a concentration of 10−6 molar and progesterone in a concentration of 10−5 molar showed optimum placental synthesis of RNA. On the other hand, the presence of a higher concentration of oestradiol than the optimum amount gave an inhibitory effect. In the case of progesterone, both the lower and higher concentrations than the optimum were inhibitory. A synergistic action on placental RNA synthesis was indicated by these hormones at their optimum concentrations. Under these conditions actinomycin D did not affect the placental RNA synthesis, suggesting a possible prevention by these hormones of the attachment of actinomycin D to the DNA chain. The DNA synthesis mechanism of the full term placenta operated at a very low efficiency and was not affected by the hormones.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
2 articles.
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