Hormone replacement in survivors of childhood cancer and brain tumors: safety and controversies

Author:

Maa van Roessel Ichelle12,Bakker Boudewijn12ORCID,van Santen Hanneke M12ORCID,Chemaitilly Wassim3ORCID

Affiliation:

1. Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center Utrecht, AB Utrecht, The Netherlands

2. Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands

3. Division of Pediatric Endocrinology, UPMC Children’s Hospitalof Pittsburgh, Pittsburgh, Pennsylvania, USA

Abstract

Childhood cancer survivors are at risk for developing endocrine disorders, including deficits in growth hormone, thyroid hormone and sex hormones. The influence these hormones have on cell growth and metabolism has raised concerns regarding the safety of their use as treatments in survivors of childhood cancer and brain tumors. This article offers a summary of current knowledge, controversies and areas for future research pertaining to this area.

Publisher

Bioscientifica

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference66 articles.

1. Childhood cancer treatments and associated endocrine late effects: a concise guide for the pediatric endocrinologist;Chemaitilly,2019

2. Hypothalamic-pituitary and growth disorders in survivors of childhood cancer: an Endocrine Society clinical practice guideline;Sklar,2018

3. Guidelines from the Dutch Childhood Oncology Group (DCOG)/SKION;Raphael,2014

4. Long term follow up of survivors of childhood cancer: a national clinical guideline,2013

5. Hypothalamic-pituitary and other endocrine surveillance among childhood cancer survivors;van Iersel,2022

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