MacroTSH: still a big problem for clinicians and clinical biochemists: lessons from a case report

Author:

Raverot Véronique1ORCID,Metrat Stéphanie1,Perrin Pauline1,Abeillon Juliette2,Lasolle Hélène2

Affiliation:

1. Hospices Civils de Lyon, Groupement Hospitalier Est, LBMMS, Centre de biologie et de pathologie Est, Lyon, France

2. Hospices Civils de Lyon, Groupement Hospitalier Est, Fédération d’Endocrinologie, Lyon, France

Abstract

MacroTSH still interferes with TSH assays. We present here a case report illustrating the difficulties that can arise in such conditions and attempt to discuss the steps involved in diagnosis.

Publisher

Bioscientifica

Reference21 articles.

1. Interferences with thyroid function immunoassays: clinical implications and detection algorithm;Favresse,2018

2. Macro TSH in patients with subclinical hypothyroidism;Hattori,2015

3. Macro-TSH: an uncommon explanation for persistent TSH elevation that thyroidologists have to keep in mind;Chiardi,2023

4. Variability in the detection of macro TSH in different immunoassay systems;Hattori,2016

5. Macro-TSH: a diagnostic challenge;Larsen,2021

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