Does single-strand DNA break repair capacity influence oocyte maintenance and quality?-Reference-Cited by-同舟云学术

Does single-strand DNA break repair capacity influence oocyte maintenance and quality?

Published:2022-12-01 Issue:6 Volume:164 Page:V15-V18
ISSN:1470-1626
Container-title:Reproduction
language:
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Author:

Giridharan Saranya¹^ORCID,Hutt Karla J¹,Winship Amy L¹^ORCID

Affiliation:

1. Ovarian Biology Laboratory, Department of Anatomy and Developmental Biology, Development and Stem Cells Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

Abstract

Human genome-wide association studies and evidence from animal models link ovarian ageing to double-strand (ds)DNA break repair capacity. Is there a connection between single-strand (ss)DNA repair mechanisms and ovarian function? We hypothesize that endogenous cellular processes subject oocytes to ssDNA lesions, and thus, ssDNA repair capacity is fundamental to their survival and maintenance.

Publisher

Bioscientifica

Subject

Cell Biology,Obstetrics and Gynecology,Endocrinology,Embryology,Reproductive Medicine

Link

https://rep.bioscientifica.com/downloadpdf/journals/rep/164/6/REP-22-0325.xml

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5. Impairment of Polβ-related DNA base-excision repair leads to ovarian aging in mice;Hua,2020

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