Affiliation:
1. 1From the Division of Endocrinology Mayo Clinic, Rochester, Minnesota, USA
2. 2Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
Abstract
The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma.
Subject
Endocrinology,Molecular Biology
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