1. 1Cardiovascular Clinical Research Facility, RDM Division of Cardiovascular Medicine, University of Oxford, Oxford, UK
2. 2School of Medicine, University of Leeds, Leeds, UK
3. 3Cardiovascular Physiology, School of Sport and Exercise Sciences, Liverpool, UK
4. 4North West Anglia NHS Foundation Trust, Bretton Gate, Bretton, Peterborough, Cambridgeshire, UK
5. 5Manchester University NHS Foundation Trust, Wythenshawe Hospital, Wythenshawe, Manchester, UK
6. 6King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
7. 7Royal United Hospitals Bath NHS Foundation Trust, Bath, UK
8. 8Department for Health, University of Bath, Bath, Somerset, UK