A systematic review of mucoadhesive vaginal tablet testing

Abstract

Drug administration through the vaginal tract is one of the oldest modalities of pharmacotherapy, and it is also one of the most explored. Since the vaginal cavity has a wide surface area, a plentiful blood supply, and a complexnetwork of blood arteries, it can evade hepatic first-pass metabolism and obtain high local drug concentrations.Vaginal pills look to be a good dose form since they are simple to use, portable, and can easily deliver therequired amount of medicine. Vaginal formulations, on the other hand, are vulnerable to rapid expulsion due tothe vaginal tract’s self-cleaning action, which reduces the formulation’s efficiency. Currently, there is an increasingamount of focus on mucoadhesive vaginal formulation research and development to fix the formulation at theplace where the medicine can be released and/or absorbed. This article examines all of the strategies used byresearchers to develop a mucoadhesive vaginal tablet that is safe, effective, and comfortable for the user.