Dynamics of Indicators of Psychoemotional Condition in Patients with Chronic Pancreatitis and Atherosclerosis on the Background of Intestinal Dysbiosis Correction

Abstract

The article describes and analyzes the psycho-emotional state indicators in patients with chronic alcoholic pancreatitis and atherosclerosis against the complex therapy background with the use of probiotics and melatonin. All patients were performed clinical-laboratory studies: lipid profile study (determination of total blood plasma cholesterol (LC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoproteins (LDL), atherogenicity coefficient (CA)); feces research on dysbiosis.  The alcoholic etiology of chronic pancreatitis was determined based on anamnestic data and using the AUDIT screening test. The dynamics of psycho-emotional disorders were studied using the HADS questionnaire and the “Emotional Condition Screening” technique. The emotional state screening was used to evaluate the subjects’ emotional state to identify critically (subclinical and pathological) abnormalities such as hypomania, somatoform, depressive, anxiety states and the tendency to abuse psychoactive substances. The intestinal dysbiosis degree was evaluated according to the classification of Kuvaeva IB, Ladodo KS. (1991). The improvement in the colon microflora was observed in all patients who received Mucofalk and melatonin additionally to the complex treatment of chronic pancreatitis and atherosclerosis. Decrease in the subclinical and clinical manifestations of anxiety and depression according to the HADS questionnaire in these patients (subclinical and clinical manifestations of anxiety from 72.1% to 38.7%; subclinical and clinical manifestations of depression from 65.9% to 36.3 %) was observed after the treatment. According to the Emotional Condition Screening technique, there was a decrease in the level of pre-clinical and clinical emotional state disorders (hypomania and somatoform disorders; depressive and anxiety states; tendency to abuse psychoactive substances). At the same time, there was an increase in the frequency of emotional state critical indicators on the background of a decrease in the emotional disorders’ frequency in general, which we also regarded as some positive dynamics in such patients.