SYNTHETIC AND BIOLOGICAL ASPECTS OF STUDYING THE PROPERTIES OF 1,2,4-TRIAZOLE DERIVATIVES

Abstract

1,2,4-triazoles belong to a well-known сlass of heterocyclic compounds that are of both theoretical and practical interest. This class has been known for about 100 years, and in recent decades 1,2,4-triazoles have become one of the most attractive objects of research in the chemistry of heterocyclic compounds due to their unique properties. Recently, a considerable number of innovative synthesis methods have been developed and interesting modification of chemical variations has been proposed, for example, a three-component reaction of aryldiazonium salts with fluorinated diazoreagents and nitriles, or a combination of a fragment of 1,2,4-triazole with coumarins or naphthalene-substituted compounds in one combined molecule, and so on. As a result, scientists have obtained new derivatives of 1,2,4-triazoles with a certain number of structural features that contribute to the production of promising substances with antimicrobial, antifungal, antitubercular, antioxidant, antitumor effects, etc. These derivatives are used not only in the medical and veterinary sphere, but also in the agricultural and industrial sectors. They have found their application as dyes, corrosion inhibitors, photosensitizers, fungicides, plant growth regulators, etc. The aim of our work was to analyze and summarize the known literature data on new synthetic approaches to the production of new derivatives of 1,2,4-triazole and systematize information related to the biological properties of these compounds.