Author:
Farias Isabela Cristina Cordeiro,Mendonça-Belmont Taciana Furtado,Silva Andreia Soares,Do Ó Kleyton Palmeira,Ferreira Felipe Borba,Medeiros Fernanda Silva,Vasconcelos Luydson Richardson Silva,Rego Moacyr Jesus Barreto de Melo,Bezerra Marcos Andre Cavalcanti,Araujo Aderson Silva,Moura Patricia Muniz Mendes Freire,Anjos Ana Claudia Mendonça,Hatzlhofer Betânia Lucena Domingues,Cavalcanti Maria do Socorro Mendonça
Abstract
The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology.
Publisher
Institute of Hematology, Catholic University
Subject
Infectious Diseases,Hematology
Cited by
8 articles.
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