Advancing lithium neutron capture therapy: 6Li-loaded nanoparticles and laser-driven neutron sources

Abstract

We report on 6Li neutron capture therapy (LiNCT) in anticipation of using carbon nanoparticles to deliver targeted, high linear energy transfer radiation to non-resectable tumors. Our investigations show that, compared with existing 10B neutron capture therapy (BNCT), 6Li offers similar dose potential for equal mass density (DLi∼DB when mLi=mB), for capture products that span 7 times more range and approximately three cell lengths. Consequently, 6Li-filled nanoparticles dispersed more than half-a-cell-length apart, better convey high doses and ultra-high dose-rates, as LiNCT generates substantially less γ-rays and becomes more targeted than BNCT. To this end, we propose a neutron production scheme involving laser-plasma driven protons incident on various 7Li targets, capable of producing >109 n/sr/pulse. For high repetition frequency, efficient neutron moderation, and ideal 6Li concentration, the modality offers greater precision than existing neutron capture therapy.