Effects of the intrinsic energy on kinetics of bio-molecules in multidimensional landscape model

Abstract

The intrinsic energy G, which is crucial for distinguishing the chemical activity of bio-molecules, plays a significant role. Various factors affecting intrinsic energy differ from simple correlations observed in the inorganic field or small organic molecular systems. To gain deeper insights into the dynamic properties within a multidimensional landscape, typical components associated with intrinsic energy, such as the pulling force F, activity distance ΔQ‡, and configurational symmetry, have been investigated. The pulling force primarily affects the x coordination and provides a quantitative measure of dynamic properties. On the other hand, estimating the influence of ΔQ‡ and configurational symmetry on intrinsic energy is complex due to their connection with configuration fluctuation properties. In this study, a statistical method was employed to investigate the fluctuation. By comparing the mean waiting time ⟨t⟩, significant differences between normal kinetics and dynamic disorder were revealed. Our findings offer a novel perspective for examining the role of intrinsic energy or potential energy in bio-molecules.