Quantitative evaluation of the low-temperature pulsed plasma-wound interaction based on splint model

Abstract

An atmospheric pressure low-temperature plasma jet has a promising application prospect in biomedical fields due to its low operating temperature and its ability to act in open space. In this paper, a mouse excisional wound splinting (MEWS) model is developed using a BALB/c strain of mice. A pulsed low-temperature plasma jet close to the human temperature is generated to treat the wound of the mouse skin. We have demonstrated that the pulsed low-temperature plasma jet can effectively promote wound healing. The large number of active particles contained in the plasma, such as reactive oxygen species, reactive nitrogen species, etc., may be responsible for its ability to increase the wound healing rate and promote skin tissue regeneration. The MEWS model adopted in this experiment reduces the interference in the evaluation of the wound healing effect caused by skin contraction and wound dressing, and thus is closer to the healing process of human wounds, and the method of wound area acquisition and calculation based on image processing reduces human interference and is more standardized, which can be used to evaluate the effect of the pulsed low-temperature plasma jet on promoting wound healing.