Abstract
A theory of fluid–solid coupling in a porous medium for application to the ultrasonic evaluation of tissue remodeling using bioelastomers is presented in this paper. A theoretical model was developed by considering the soft porous bioelastomer as a fluid-saturated solid. Taking into account the relative motion between the fluid and solid in an aggregate, we derived an expression for a characteristic fluid–solid coupling parameter that can be employed as a measure of tissue recovery. Four cases were studied to investigate the dependence of the fluid–solid coupling parameter on related variables. The theory has potential applications in the acellular in situ tissue engineering for noninvasive monitoring of the complex mechanical remodeling process of tissue regeneration and bioelastomer degradation.
Funder
National Natural Science Foundation of China