Affiliation:
1. Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing 100124, People's Republic of China
2. Department of Engineering Mechanics, Tsinghua University, Beijing 100084, People's Republic of China
Abstract
In the fields of organ printing and drug preparation, high-precision and stable dispersion of high-viscosity biomaterials enable precise control of organ morphology and drug release rate. This paper proposes the use of an acoustic surface wave to overcome the problem of unstable interface breakup and weak size controllability when the traditional passive droplet microfluidics is applied to high-viscosity (higher than 0.4 Pa·s) dispersed phases. This paper studies the internal flow behavior of high-viscosity fluid under the influence of an acoustic field and realizes the accurate prediction of formation regime and droplet size. Experimental results show that with the increase in acoustic power, three unique droplet generation regimes (e.g., long jetting, transition, and dripping) exist. The transition regime is most suitable for high-throughput preparation of high-viscosity droplets, and its corresponding flow and acoustic conditions can be predicted by equation μd/ μc = 4.8 × 10−8 ( μc × vc/ A[Formula: see text] × w)−3.32. Affected by the regime transition, the droplet size increases with the increase in acoustic power. The droplet size prediction can be realized based on the capillary number Caf, which represents the intensity of the acoustic field.
Funder
National Natural Science Foundation of China
Subject
Condensed Matter Physics,Fluid Flow and Transfer Processes,Mechanics of Materials,Computational Mechanics,Mechanical Engineering
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献