Affiliation:
1. School of Mechanical and Mechatronic Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, New South Wales, Australia
Abstract
Complementing computational fluid dynamics (CFD) simulations with machine learning algorithms is becoming increasingly popular as the combination reduces the computational time of the CFD simulations required for classifying, predicting, or optimizing the impact of geometrical and physical variables of a specific study. The main target of drug delivery studies is indicating the optimum particle diameter for targeting particular locations in the lung to achieve a desired therapeutic effect. In addition, the main goal of molecular dynamics studies is to investigate particle–lung interaction through given particle properties. Therefore, this study combines the two by numerically determining the optimum particle diameter required to obtain an ideal striking velocity magnitude (velocity at the time of striking the alveoli, i.e., deposition by sedimentation/diffusion) and impact time (time from release until deposition) inside an acinar part of the lung. At first, the striking velocity magnitudes and time for impact (two independent properties) of three different particle diameters ([Formula: see text]) are computed using CFD simulations. Then, machine learning classifiers determine the particle diameter corresponding to these two independent properties. In this study, two cases are compared: A healthy acinus where a surfactant layer covers the inner surface of the alveoli providing low air–liquid surface tension values [Formula: see text]), and a diseased acinus where only a water layer covers the surface causing high surface tension values [Formula: see text]). In this study, the airflow velocity throughout the breathing cycle corresponds to a person with a respiratory rate of 13 breaths per minute and a volume flow rate of [Formula: see text]. Accurate machine learning results showed that all three particle diameters attain larger velocities and smaller impact times in a diseased acinus compared to a healthy one. In both cases, the [Formula: see text] particles acquire the smallest velocities and longest impact times, while the [Formula: see text] particles possess the largest velocities and shortest impact times.
Subject
Condensed Matter Physics,Fluid Flow and Transfer Processes,Mechanics of Materials,Computational Mechanics,Mechanical Engineering
Cited by
5 articles.
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