Breathing in danger: Mapping microplastic migration in the human respiratory system

Abstract

The abundance of air pollutants over the last few years, including the concentration of microplastics, has become an alarming concern across the world. Initially discovered in marine life, these toxic and inflammatory particles have recently been found in human lung tissues. When inhaled, these harmful particles settle down in the lung airways and, over time, lead to respiratory failures. A recent study analyzed the microplastic transport behavior in the mouth–throat airways. However, the knowledge of the microplastic migration in bifurcating tracheobronchial airways is missing in the literature. Therefore, this first-ever study analyzes in detail the transport behavior and settling patterns of microplastic particles of different sizes and shapes at different respiratory intensities in the tracheobronchial lung airways. A numerical technique based on discrete phase modeling is employed to simulate the flow of microplastic particles in a three-dimensional realistic lung geometry. The numerical model results indicate low velocity and turbulence intensity magnitudes with smooth flow in the trachea compared to the airways of left and right lobes, which experience higher velocities and generate secondary vortices. Lower lung lobes are the deposition hotspots for the harmful microplastic particles at a lower flow rate. These hotspots shift to upper lung lobes at a higher flow rate for the same particle size. Moreover, microplastic particle size and shape influence the overall deposition rate in the tracheobronchial lung airways. The results of the current study, including microplastic accumulation regions at different breathing intensities, will contribute to the updated knowledge of pollutant inhalation and facilitate relevant treatment measures.