Quantitative microwave-induced thermoacoustic microscopy

Abstract

Visualization and analysis of microstructure of materials or tissue play a pivotal role in industrial manufacturing and pathological diagnosis. Microwave-induced thermoacoustic microscopy (TAM) enables imaging at the microscopic level. TAM, however, is currently qualitative and cannot quantitatively measure intrinsic electromagnetic parameters of materials/tissue, such as conductivity. Here, we propose a quantitative microwave-induced thermoacoustic microscopy (qTAM) approach capable of quantitatively recovering conductivity using a finite element-based iterative inversion strategy coupled with thermoacoustic measurements. We validate the qTAM approach using tissue-mimicking phantoms, and demonstrate its applications to imaging flexible circuits, ex vivo rabbit bone, and rat brain tissues. The results obtained suggest that qTAM may have the potential to become a quantitative tool for microscopic imaging of materials and tissues.