Development of in-vitro pulsatile flow generator for evaluating the performance of hemodialysis catheters

Author:

Cho Seongsu1ORCID,Lee Jihyeong1,Park Sun Cheol2,Park Hoon Suk3ORCID,Lee Dae Hee4,Lee Jinkee15ORCID

Affiliation:

1. School of Mechanical Engineering, Sungkyunkwan University 1 , Suwon 16419, Republic of Korea

2. Division of Vascular and Transplant Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea 2 , Seoul 06591, Republic of Korea

3. Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea 3 , Seoul 06591, Republic of Korea

4. Sungwon Medical Co., Ltd. 4 , Cheongju 28174, Republic of Korea

5. Institute of Quantum Biophysics (IQB), Sungkyunkwan University 5 , Suwon 16419, Republic of Korea

Abstract

Hemodialysis (HD) using an HD catheter is performed widely on renal failure patients. The catheter was evaluated using the recirculation ratio in pre-clinical status, which is a crucial index indicating its performance. However, pre-clinical in-vivo experiments have limitations: high cost, and ethical issues. Hence, computational and in-vitro methods have been developed as alternatives. However, computational methods require fluid dynamic knowledge, whereas in-vitro experiments are complicated and expensive. In this study, we developed a pulsatile flow generator to mimic blood flow achieving cost effectiveness and user convenience. The device used iterative learning control, achieving blood flow in the superior and inferior vena cava within a 3.3% error. Furthermore, the recirculation ratios were measured based on two insertion directions and two different external pipe materials to evaluate the catheter regarding patients’ posture and blood vessel stiffness. The results provide a better understanding of cardiovascular device performance without complicated and costly pre-clinical tests.

Funder

National Research Foundation of Korea

Publisher

AIP Publishing

Subject

Instrumentation

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