Microneedle arrays integrated with microfluidic systems: Emerging applications and fluid flow modeling

Author:

Ahmadpour Abdollah1ORCID,Isgor Pelin Kubra2ORCID,Ural Berk1ORCID,Eren Busra Nimet1ORCID,Sarabi Misagh Rezapour1ORCID,Muradoglu Metin1ORCID,Tasoglu Savas134567ORCID

Affiliation:

1. Department of Mechanical Engineering, College of Engineering, Koç University 1 , Türkiye

2. Department of Biomedical Sciences and Engineering, College of Engineering, Koç University 2 , Türkiye

3. Department of Physical Intelligence, Max Planck Institute for Intelligent Systems 3 , Stuttgart 70569, Germany

4. Koç University Translational Medicine Research Center (KUTTAM), Koç University 4 , Istanbul 34450, Türkiye

5. Koç University Arçelik Research Center for Creative Industries (KUAR), Koç University 5 , Istanbul 34450, Türkiye

6. Boğaziçi Institute of Biomedical Engineering, Boğaziçi University 6 , Istanbul 34684, Türkiye

7. Koç University Is Bank Artificial Intelligence Lab (KUIS AI Lab), Koç University 7 , Istanbul 34450, Türkiye

Abstract

Microneedle arrays are patches of needles at micro- and nano-scale, which are competent and versatile technologies that have been merged with microfluidic systems to construct more capable devices for biomedical applications, such as drug delivery, wound healing, biosensing, and sampling body fluids. In this paper, several designs and applications are reviewed. In addition, modeling approaches used in microneedle designs for fluid flow and mass transfer are discussed, and the challenges are highlighted.

Funder

Tubitak 2232 International Fellowship for Outstanding Researchers Award

Alexander von Humboldt Research Fellowship for Experienced Researchers

Marie Sklodowska-Curie Individual Fellowship

Royal Academy Newton-Katip Celebi Transforming Systems Through Partnership Award

Bilim Kahramanlari Dernegi The Young Scientist Award

Science Academy's Young Scientist Awards Program

Outstanding Young Scientists Awards

Publisher

AIP Publishing

Subject

Condensed Matter Physics,General Materials Science,Fluid Flow and Transfer Processes,Colloid and Surface Chemistry,Biomedical Engineering

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