Tipping points of evolving epidemiological networks: Machine learning-assisted, data-driven effective modeling

Author:

Evangelou Nikolaos1ORCID,Cui Tianqi1ORCID,Bello-Rivas Juan M.1ORCID,Makeev Alexei2,Kevrekidis Ioannis G.1ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, Johns Hopkins University 1 , Baltimore, Maryland 21218, USA

2. Faculty of Computational Mathematics and Cybernetics, Moscow State University 2 , 119991 Moscow, Russia

Abstract

We study the tipping point collective dynamics of an adaptive susceptible–infected–susceptible (SIS) epidemiological network in a data-driven, machine learning-assisted manner. We identify a parameter-dependent effective stochastic differential equation (eSDE) in terms of physically meaningful coarse mean-field variables through a deep-learning ResNet architecture inspired by numerical stochastic integrators. We construct an approximate effective bifurcation diagram based on the identified drift term of the eSDE and contrast it with the mean-field SIS model bifurcation diagram. We observe a subcritical Hopf bifurcation in the evolving network’s effective SIS dynamics that causes the tipping point behavior; this takes the form of large amplitude collective oscillations that spontaneously—yet rarely—arise from the neighborhood of a (noisy) stationary state. We study the statistics of these rare events both through repeated brute force simulations and by using established mathematical/computational tools exploiting the right-hand side of the identified SDE. We demonstrate that such a collective SDE can also be identified (and the rare event computations also performed) in terms of data-driven coarse observables, obtained here via manifold learning techniques, in particular, Diffusion Maps. The workflow of our study is straightforwardly applicable to other complex dynamic problems exhibiting tipping point dynamics.

Funder

Air Force Office of Scientific Research

U.S. Department of Energy

National Science Foundation

Publisher

AIP Publishing

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