Optical-visualized photoacoustic tomographic navigation

Author:

Wang Li12ORCID,Ke Di12ORCID,Xin Haishu12ORCID,Liu Rui12ORCID,Pan Shu12ORCID,Xiong Kedi12ORCID,Yang Sihua12ORCID

Affiliation:

1. MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University 1 , Guangzhou 510631, China

2. Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University 2 , Guangzhou 510631, China

Abstract

The current preoperative vascular imaging methods cannot achieve noninvasive high-resolution imaging of deep-localized vessels. Photoacoustic tomography (PAT) can show microvessels with centimeter depth and submillimeter diameter without the use of contrast agents. Combined with PAT and optical projection technology, the Hessian-matrix-based skin removal algorithm and the target matching method were developed to spatially align the photoacoustic data of subcutaneous blood vessels with the anatomy of real patients and to realize three-dimensional (3D) visualization of blood vessels from the body surface. The optical projection navigation system based on PAT has high spatial resolution (∼135 μm) and temporal resolution (0.1 s). In the rabbit injection experiment, 3D distributions of needle and blood vessel (>100 μm) were obtained by image segmentation, which proved that the method can guide micro plastic injection. Furthermore, healthy volunteers' forehead imaging experiments show that 3D visualization and cross-sectional images of the human forehead clearly show the vascular network and ability of the system to image submillimeter blood vessels with penetration depth (∼10.2 mm). Our work confirms that the method of integrated photoacoustic imaging and optical projection has great potential for noninvasive diagnosis and treatment of clinical blood vessels, opening a path for the application of photonics in medical esthetics.

Publisher

AIP Publishing

Subject

Physics and Astronomy (miscellaneous)

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