How effective is direct targeting of genes instead of gene products in providing promising lead: Lessons from discovery of naphthyridine-azaquinilone as lead for Huntington ’s disease
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Publisher
AIP Publishing
Link
http://aip.scitation.org/doi/pdf/10.1063/5.0193240
Reference20 articles.
1. Huntington's disease: a clinical review
2. P. McColgan and S. J. Tabrizi, Huntington’s disease: a clinical review. European Journal of Neurology 25, 24-34 (2018).
3. Medline Plus, https://medlineplus.gov/genetics/condition/huntington-disease/#genes (Accessed on Jun-2021)
4. Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset
5. Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis
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