Global dynamics, thermodynamics and non-equilibrium origin of bifurcations for single neuron dynamics

Abstract

The understanding of neural excitability and oscillations in single neuron dynamics remains incomplete in terms of global stabilities and the underlying mechanisms for phase formation and associated phase transitions. In this study, we investigate the mechanism of single neuron excitability and spontaneous oscillations by analyzing the potential landscape and curl flux. The topological features of the landscape play a crucial role in assessing the stability of resting states and the robustness/coherence of oscillations. We analyze the excitation characteristics in Class I and Class II neurons and establish their relation to biological function. Our findings reveal that the average curl flux and associated entropy production exhibit significant changes near bifurcation or phase transition points. Moreover, the curl flux and entropy production offer insights into the dynamical and thermodynamical origins of nonequilibrium phase transitions and exhibit distinct behaviors in Class I and Class II neurons. Additionally, we quantify time irreversibility through the difference in cross-correlation functions in both forward and backward time, providing potential indicators for the emergence of nonequilibrium phase transitions in single neurons.