Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles-Reference-Cited by-同舟云学术

Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles

Published:2023-02-01 Issue:2 Volume:13 Page:
ISSN:2158-3226
Container-title:AIP Advances
language:en
Short-container-title:

Author:

Hirota Ryuichi¹^ORCID,Murayama Toru¹,Katsumi Ryota²^ORCID,Kawawaki Tokuhisa³^ORCID,Yabukami Shin¹⁴,Igarashi Ryuji⁵^ORCID,Negishi Yuichi³^ORCID,Kusakabe Moriaki⁶⁷^ORCID,Sekino Masaki⁸^ORCID,Yatsui Takashi²^ORCID,Kuwahata Akihiro¹^ORCID

Affiliation:

1. Graduate School of Engineering, Tohoku University 1 , Sendai, Miyagi 980-8579, Japan

2. Graduate School of Engineering, Toyohashi University of Technology 2 , Toyohashi, Aichi 441-8580, Japan

3. Department of Applied Chemistry, Faculty of Science, Tokyo University of Science 3 , Tokyo 162-8601, Japan

4. Faculty of Engineering, Tohoku Gakuin University 4 , Sendai, Miyagi 985-8537, Japan

5. Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology 5 , Chiba 263-8555, Japan

6. Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo 6 , Tokyo 113-8657, Japan

7. Matrix Cell Research Institute Inc. 7 , Ibaraki 300-1232, Japan

8. Graduate School of Engineering, The University of Tokyo 8 , Tokyo 113-8656, Japan

Abstract

Virus detection methods based on nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic are widely applied, owing to their high sensitivity and short measurement time. This paper proposes a virus detection method based on the second harmonic because of its larger signal component. We found that the second harmonic signal is superior to the third harmonic signal for small nanobeads and a large change of the second harmonic signal in the signal-to-noise ratio (SNR) with nanobeads concentration. In addition, a virus detection limit of 100 pg/ml is achieved. Therefore, the proposed method can potentially be utilized for rapid screening of viruses.

Funder

Uehara Memorial Foundation

Hitachi Global Foundation

Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering

Adaptable and Seamless Technology Transfer Program Through Target-Driven R and D

Japan Agency for Medical Research and Development

High Energy Accelerator Research Organization

Publisher

AIP Publishing

Subject

General Physics and Astronomy

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