Microfluidic pressure-driven flow of a pair of deformable particles suspended in Newtonian and viscoelastic media: A numerical study

Abstract

The manipulation and control of microparticles through non-intrusive methods is pivotal in biomedical applications such as cell sorting and cell focusing. Although several experimental and numerical studies have been dedicated to single suspended particles or clusters of rigid spheres, analogous cases with deformable particles have not been as thoroughly studied, especially when the suspending liquid exhibits relevant viscoelastic properties. With the goal of expanding the current knowledge concerning these systems, we perform a computational study on the hydrodynamic interactions between two neutrally buoyant initially spherical elastic particles suspended in Newtonian and shear-thinning viscoelastic matrices subjected to pressure-driven flow in a cylindrical microchannel. Due to the well-known focusing mechanism induced by both particle deformability and fluid elasticity, the two particles are assumed to flow at the axis of the tube. The rheological behavior of the viscoelastic continuous phase is modeled via the Giesekus constitutive equation, whereas the particles are assumed to behave as neo-Hookean solids. The problem is tackled by employing a mixed finite-element method. The effects of particle deformability, fluid elasticity, confinement ratio, and initial interparticle separation distance on the pair dynamics are investigated. The main outcome of this study is a quantitative indication of the flow conditions and spatial configurations (initial distances) under which the particles will spontaneously form organized structures. Such results are helpful to design efficient microfluidic devices with the aim of promoting particle ordering.