Design of eco-friendly antifreeze peptides as novel inhibitors of gas-hydration kinetics

Author:

Zhang Nan1ORCID,Zhu Ying1,Li Yan-Nan1,Zhang Li-Rong1ORCID,Zhang Feng-Shou2ORCID,Liu Jun-Jie1ORCID

Affiliation:

1. Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University 1 , Hohhot 010021, China

2. The Key Laboratory of Beam Technology and Material Modification of Ministry of Education, College of Nuclear Science and Technology, Beijing Normal University 2 , Beijing 100875, China

Abstract

In this study, peptides designed using fragments of an antifreeze protein (AFP) from the freeze-tolerant insect Tenebrio molitor, TmAFP, were evaluated as inhibitors of clathrate hydrate formation. It was found that these peptides exhibit inhibitory effects by both direct and indirect mechanisms. The direct mechanism involves the displacement of methane molecules by hydrophobic methyl groups from threonine residues, preventing their diffusion to the hydrate surface. The indirect mechanism is characterized by the formation of cylindrical gas bubbles, the morphology of which reduces the pressure difference at the bubble interface, thereby slowing methane transport. The transfer of methane to the hydrate interface is primarily dominated by gas bubbles in the presence of antifreeze peptides. Spherical bubbles facilitate methane migration and potentially accelerate hydrate formation; conversely, the promotion of a cylindrical bubble morphology by two of the designed systems was found to mitigate this effect, leading to slower methane transport and reduced hydrate growth. These findings provide valuable guidance for the design of effective peptide-based inhibitors of natural-gas hydrate formation with potential applications in the energy and environmental sectors.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Inner Mongolia Autonomous Region

Publisher

AIP Publishing

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