Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the FcγRIa (CD64) Receptor-Reference-Cited by-同舟云学术

Dataset from HDX-MS Studies of IgG1 Glycoforms and Their Interactions with the FcγRIa (CD64) Receptor

Published:2021-06-17 Issue: Volume:126 Page:
ISSN:2165-7254
Container-title:Journal of Research of the National Institute of Standards and Technology
language:en
Short-container-title:J. RES. NATL. INST. STAN.

Author:

Anderson Kyle W.¹²,Scott Kerry³²,Karageorgos Ioannis L.¹²,Gallagher Elyssia S.³²,Venkata S. Tayi⁴,Butler Michael⁴⁵,Hudgens Jeffrey W.¹²

Affiliation:

1. National Institute of Standards and Technology, Material Measurement Laboratory, Biomolecular Measurement Division, Gaithersburg, MD 20899, USA

2. Institute for Bioscience and Biotechnology Research, 9600 Gudelsky Drive, Rockville, MD 20850, USA

3. National Institute of Standards and Technology, Gaithersburg, MD 20899, USA

4. Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Canada

5. National Institute for Bioprocessing Research and Training, Foster Avenue, Mount Merrion, Blackrock, Co. Dublin, Ireland

Abstract

This document presents hydrogen-deuterium exchange mass spectrometry (HDX-MS) data from measurements of three purified IgG1 glycoform samples, predominantly G0F, G2F, and SAF, in isolation and in complexation with the high-affinity receptor, FcγRIa (CD64). The IgG1 antibody used in this study, aIL8hFc, is a murine-human chimeric IgG1, which inhibits IL-8 binding to human neutrophils.

Funder

Material Measurement Laboratory

Publisher

National Institute of Standards and Technology (NIST)

Subject

General Engineering

Reference39 articles.

1. Progress and Challenges in the Design and Clinical Development of Antibodies for Cancer Therapy

2. The B Cell Slayer

3. Current evaluation of alemtuzumab in multiple sclerosis

4. Secukinumab may be a valid treatment option in patients with CNS demyelination and concurrent ankylosing spondylitis: Report of two clinical cases

5. Monoclonal antibodies for treating osteoporosis

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