Affiliation:
1. National Institute of Standards and Technology, Material Measurement Laboratory, Biomolecular Measurement Division, Gaithersburg, MD 20899, USA
Abstract
This tutorial provides mechanical drawings, electrical schematics, parts lists,
stereolithography (STL) files for producing three-dimensional (3D)-printed parts,
initial graphics exchange specification (IGS) files for automated machining, and
instructions necessary for construction of a dual protease column, subzero, liquid
chromatography system for hydrogen-deuterium exchange mass spectrometry (HDX-MS).
Electro-mechanical schematics for construction of two multi-zone temperature controllers
that regulate to ±0.05 oC are also included in this tutorial.
Funder
Material Measurement Laboratory
Publisher
National Institute of Standards and Technology (NIST)
Reference22 articles.
1. Weis DD ed (2016) Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods, and Applications (John Wiley & Sons, Ltd., Chichester),1st Ed.
2. A Retrospective Evaluation of the Use of Mass Spectrometry in FDA Biologics License Applications
3. Gutierrez-Lugo M (2016) Regulatory consideration for the characterization of HOS in biotechnology products. HOS 2016, ed Olson R (CASSS, Long Beach, CA).
4. Recent advancements, challenges, and practical considerations in the mass spectrometry-based analytics of protein biotherapeutics: A viewpoint from the biosimilar industry
5. The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies
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