The enduring legacy of the “constant-field equation” in membrane ion transport-Reference-Cited by-同舟云学术

The enduring legacy of the “constant-field equation” in membrane ion transport

Published:2017-09-20 Issue:10 Volume:149 Page:911-920
ISSN:0022-1295
Container-title:Journal of General Physiology
language:en
Short-container-title:

Author:

Alvarez Osvaldo¹^ORCID,Latorre Ramon²^ORCID

Affiliation:

1. Departamento de Biología, Facultad de Ciencias, Santiago, Chile

2. Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile

Abstract

In 1943, David Goldman published a seminal paper in The Journal of General Physiology that reported a concise expression for the membrane current as a function of ion concentrations and voltage. This body of work was, and still is, the theoretical pillar used to interpret the relationship between a cell’s membrane potential and its external and/or internal ionic composition. Here, we describe from an historical perspective the theory underlying the constant-field equation and its application to membrane ion transport.

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

Centro Interdisciplinario de Neurociencia de Valparaíso

Air Force Office of Scientific Research

Publisher

Rockefeller University Press

Subject

Physiology

Link

http://rupress.org/jgp/article-pdf/149/10/911/1233182/jgp_201711839.pdf

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