THE REVERSIBLE INACTIVATION OF TOBACCO MOSAIC VIRUS BY CRYSTALLINE RIBONUCLEASE-Reference-Cited by-同舟云学术

THE REVERSIBLE INACTIVATION OF TOBACCO MOSAIC VIRUS BY CRYSTALLINE RIBONUCLEASE

Published:1942-01-20 Issue:3 Volume:25 Page:497-505
ISSN:1540-7748
Container-title:Journal of General Physiology
language:en
Short-container-title:

Author:

Loring Hubert S.¹

Affiliation:

1. From the Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, New Jersey, and The Department of Chemistry, Stanford University, California

Abstract

The reversible inactivation of tobacco mosaic virus by crystalline ribonuclease is reported. Studies on the effect of time of standing on the amount of inactivation, and on the effect of dilution and repeated high speed centrifugation on the recovery of virus activity, and the preparation of an insoluble virus-enzyme complex show that the inactivation is brought about at least in part by a combination between virus and enzyme. The significance of the fact that ribonuclease has no detectable effect on the virus nucleic acid when the latter is in combination with protein in the form of virus is discussed with respect to the structure of the virus.

Publisher

Rockefeller University Press

Subject

Physiology

Link

http://rupress.org/jgp/article-pdf/25/3/497/1239358/497.pdf

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