THE POTENTIOMETRIC ANALYSIS OF MEMBRANE STRUCTURE AND ITS APPLICATION TO LIVING ANIMAL MEMBRANES

Author:

Meyer Kurt H.1,Bernfeld P.1

Affiliation:

1. From the Laboratory of Inorganic and Organic Chemistry, University of Geneva, Switzerland

Abstract

1. The electromotive forces which arise, if two electrolyte solutions are separated from each other by a layer of any kind, are discussed. A general equation is derived comprising the known equations for diffusion, partition, and membrane (Donnan) potentials as special cases. 2. A method is proposed to analyse membranes potentiometrically with respect to their cation or anion selectivity, their dissolving power for ions, and their influence on ion mobility (migration velocity). 3. The possibility of analysing a membrane composed of several layers of different permeability is discussed. 4. The investigation of the skin of the belly of Rana temporaria leads to the following results. It is composed of at least four layers of different permeability, one of which is specifically permeable to H ions and is very likely identical with the "basal membrane" situated between the stratum germinativum and the corium. The major part of the resting potential of the skin is located across this membrane and is due to the difference of H+ concentrations on both sides of the membrane. 5. Experiments on muscle show that the sarcolemma is specifically permeable to H ions. The injury potential of the muscle is attributed to the difference of H+ concentration inside and outside the fibre.

Publisher

Rockefeller University Press

Subject

Physiology

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1. Techniques of Epithelial Transport Physiology;Physiology in Health and Disease;2020

2. A THEORY OF CONNECTIVE TISSUE BEHAVIOR: ITS IMPLICATIONS IN PERIODONTAL DISEASE*;Annals of the New York Academy of Sciences;2006-12-15

3. Some Aspects of the Application of Tracers in Permeability Studies;Advances in Enzymology - and Related Areas of Molecular Biology;2006-11-22

4. Oscillation of the electric potential of frog skin under the effect of Li+: Experimental approach;The Journal of Membrane Biology;1980-06

5. Evaluation of membrane surface charge density: A discussion of some models;Bulletin of Mathematical Biology;1977-11

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