Affiliation:
1. From the Department of Physiology, Western Reserve University Medical School, Cleveland
Abstract
Formulae are derived for the time-intensity relations for stimulation by direct currents using the following hypotheses: first, the current produces an excitatory effect whose rate of growth is proportional to the voltage; and second, the tissue reacts toward the normal state at a rate proportional to the amount of excitation. If p represents the local excitatory process numerically, the hypotheses are represented by the differential equation
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where K and k are constants and V the applied voltage. For the stimulus to be adequate it is assumed that p must be built up to a certain liminal value. It appears as a deduction from the data that this liminal value is a function of the voltage of the form h ± αV where h and α are constants. α is zero or negligible for certain electrodes. αV is a measure of electrotonus or a similar phenomenon. Experimental data are discussed and are shown to agree satisfactorily with the derived formulae for stimulation both at the anode and cathode.
Publisher
Rockefeller University Press
Cited by
146 articles.
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