Novel cardiac myosin inhibitor for hypertrophic cardiomyopathy
Author:
Affiliation:
1. University of Miami, Miller School of Medicine 1 Department of Molecular and Cellular Pharmacology, , Miami, FL, USA
Abstract
Funder
National Institutes of Health
Publisher
Rockefeller University Press
Link
https://rupress.org/jgp/article-pdf/doi/10.1085/jgp.202413640/1931378/jgp_202413640.pdf
Reference25 articles.
1. Genetic basis of hypertrophic cardiomyopathy: From bench to the clinics;Alcalai;J. Cardiovasc. Electrophysiol.,2008
2. Deciphering the super relaxed state of human beta-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers;Anderson;Proc. Natl. Acad. Sci. USA,2018
3. Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite opposite effects in heart contraction;Auguin;Nat. Commun.,2024
4. Sudden cardiac death in famous athletes, lessons learned, heterogeneity in expert recommendations and pitfalls of contemporary screening strategies;Bickel;J. Atr. Fibrillation,2019
5. Discovery of aficamten (CK-274), a next-generation cardiac myosin inhibitor for the treatment of hypertrophic cardiomyopathy;Chuang;J. Med. Chem.,2021
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