Affiliation:
1. Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA
Abstract
Calcium gluconate has been empirically administered to hasten recovery of force during an episode of periodic paralysis. By using a genetically engineered mouse model, Uwera and colleagues show that low Ca2+ clearly promotes a loss of force in affected muscle, thereby providing the first evidence for the benefit of maintaining normal Ca2+ levels in this disorder.
Funder
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Publisher
Rockefeller University Press
Reference12 articles.
1. Effects of extracellular calcium on calcium movements of excitation-contraction coupling in frog skeletal muscle fibres;Brum;J. Physiol,1988
2. Channelopathies of skeletal muscle excitability;Cannon;Compr. Physiol,2015
3. Adynamia episodica hereditaria;Gamstorp;Acta Paediatr. (Stockh.),1956
4. Slow inactivation differs among mutant Na channels associated with myotonia and periodic paralysis;Hayward;Biophys. J,1997
5. Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness;Hayward;J. Clin. Invest,2008
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献