Molecular Aspects of Hepatocellular Carcinoma

Author:

Abou-Shady 1,Baer 1,Friess 1,Zimmermann 2,Büchler 1

Affiliation:

1. Department of Visceral and Transplantation Surgery (Chairman: Prof. M.W. Büchler), University of Bern, Inselspital, Bern, Switzerland

2. Institute of Pathology, University of Bern, Switzerland

Abstract

Hepatocellular carcinoma (HCC) is a highly malignant tumor with a poor prognosis. The success of its established treatment modalities is frequently limited by the advanced stage of the tumor at the time of diagnosis. Therefore, it is important to understand the mechanisms that control its growth behavior. In the present study, we review some aspects of molecular and cellular processes involved in growth control and metastatic potential of HCC. These include some growth factors and their receptors, oncogenes and tumor suppressor genes, and factors that control angiogenesis and extracellular matrix formation. These factors may be important targets for novel therapeutic approaches in the future.

Publisher

Hogrefe Publishing Group

Subject

Surgery

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