Advantage in Aging Cognition Associated with the <i>CREBRF</i> variant rs373863828 Among Samoans-Reference-Cited by-同舟云学术

Advantage in Aging Cognition Associated with the CREBRF variant rs373863828 Among Samoans

Published:2024-05-22 Issue: Volume: Page:
ISSN:1662-9647
Container-title:GeroPsych
language:en
Short-container-title:GeroPsych

Author:

Levy Becca R.¹²^ORCID,Viali Satupa’itea³,Naseri Take⁴,Reupena Muagututia Sefuiva⁵,Faasalele-Savusa Kima⁶,Filipo Vaimoana⁶,Kershaw Erin E.⁷^ORCID,Huang Yuan⁸^ORCID,Slade Martin D.⁹^ORCID

Affiliation:

1. Department of Social Behavioral Sciences, Yale School of Public Health, New Haven, CT, USA

2. Department of Psychology, Yale University, New Haven, CT, USA

3. Samoan National University, Apia, Samoa

4. Ministry of Health, Government of Samoa, Apia, Samoa

5. Bureau of Statistics, Government of Samoa, Apia, Samoa

6. Samoan Obesity, Lifestyle, and Genetic Adaptations Study Group, Apia, Samoa and Yale School of Public Health, New Haven, CT, USA

7. Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA

8. Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA

9. Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA

Abstract

Abstract: We examined whether the A allele of CREBRF rs373863828, which is common in Samoans but rare in non-Pacific Islanders, predicts better cognition. Samoan interviewers interviewed participants who were 60 years and older, lived in the Independent State of Samoa, and had four Samoan grandparents. The AA genotype significantly predicted older Samoans’ better subjective and objective cognition; it also contributed 5.9 times more than APOE to subjective cognition and 12.3 times more than APOE to objective cognition, in effect-size analyses. Since CREBRF operates in the universal CREB system, the findings could inform general aging-cognition resilience.

Publisher

Hogrefe Publishing Group

Link

https://econtent.hogrefe.com/doi/pdf/10.1024/1662-9647/a000338

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