Cohort Differences in the Association of Cardiovascular Risk and Cognitive Aging

Author:

Karlsson Peter12,Johansson Boo1,Skoog Ingmar3,Skoog Johan1,Rydén Lina3,Thorvaldsson Valgeir1

Affiliation:

1. Department of Psychology, University of Gothenburg, Sweden

2. School of Health and Welfare, Halmstad University, Sweden

3. Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Sweden

Abstract

Abstract. Aim: To investigate birth cohort differences in associations between cardiovascular risk and fluid cognition between the age of 70 and 79. Method: Data were drawn from representative population-based cohort samples (H70), born 1901–1902, 1906–1907, and 1930, measured at ages 70, 75, and 79 on fluid cognitive measures (spatial ability and logical reasoning). The Framingham Risk Score (FRS), derived from office-based nonlaboratory predictors (age, sex, systolic blood pressure, BMI, smoking, diabetes status), was used to measure cardiovascular risk. Multiple-group latent growth curve models were fitted to the data. Findings: Estimates revealed small associations between the FRS and fluid cognition. These associations were slightly reduced in the 1930 cohort. Conclusion: Findings suggest diminishing adverse effects of cardiovascular risk on cognitive aging in cohorts born later.

Publisher

Hogrefe Publishing Group

Subject

Geriatrics and Gerontology,Gerontology

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