Species-dependent premature degradation of absorbable suture materials caused by infection – Impact on the choice of thread in vascular surgery

Abstract

Background: In case of infection after vascular reconstruction, preference is often given to absorbable suture material with the aim of preventing persistence of infection. We have investigated the functional deficit of absorbable sutures on incubation with various different bacteria. Material and methods: Four suture materials – Dexon bicolor®, Vicryl®, Maxon® and PDS II® – were placed in contact with reference bacterial cultures (Staphylococcus aureus, Pseudomonas aeroginosa, E. coli, coagulase-negative staphylococci and Proteus mirabilis). The bacteria were incubated for 7 days at 37°C, together with the suture material. A logarithmic phase (Group A) and a static phase (Group B) were simulated. The linear tensile strength (LTS) of the suture material was measured (Instron Tensiometer). Results: In the case of Staphylococcus aureus, a significant decrease in LTS was established for Dexon bicolor® (group A: 31%, group B: 22%), and Vicryl® (53% and 43%), but not for the monofilament threads. With regard to the other bacteria, a considerably more dramatic effect was observed: in both groups the braided sutures had completely disintegrated after 7 days. The monofilament sutures also revealed a significant loss of function (Maxon®: 88%, PDS II® 66%). Conclusions: The absorbable sutures revealed a premature, species-dependent loss of function due to the presence of the bacteria. On the basis of our results, the use of absorbable threads for vessel sutures in case of infection cannot be recommended, with the exception of monofilament material in a monocultural Staphylococcus aureus infection.